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Captive Leopardus cats may also display affectionate behavior toward humans, but were not domesticated. House cats often mate with feral cats producing hybrids such as the Kellas cat in Scotland. Hybridisation between domestic and other Felinae species is also possible. Development of cat breeds started in the mid 19th century. An analysis of the domestic cat genome revealed that the ancestral wildcat genome was significantly altered in the process of domestication, as specific mutations were selected to develop cat breeds. Most breeds are founded on random-bred domestic cats. Genetic diversity of these breeds varies between regions, and is lowest in purebred populations, which show more than 20 deleterious genetic disorders.

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